Frontiers in Medical Science Research, 2026, 8(3); doi: 10.25236/FMSR.2026.080305.
Xianfeng Kuang1,2, Shaoquan Pu1,2
1920th Hospital of Joint Logistics Support Force, Kunming, Yunnan, 650032, China
2Kunming Medical University, Kunming, Yunnan, 650500, China
Malignant neoplasms of bone and articular cartilage (MNBAC) affect children, adolescents, and young adults (CAYA, 0–39 years), but global burden trends remain unclear due to insufficient age-stratified assessments. Using 1990–2021 Global Burden of Disease (GBD) data from 204 regions, we analyzed age-standardized prevalence (ASPR) and disability-adjusted life-year (ASDR) rates via Joinpoint regression, age-period-cohort (APC) models, ARIMA forecasting, and Socio-demographic Index (SDI) correlation analysis. Globally, ASPR increased (AAPC=0.49%) while ASDR remained stable (AAPC=0.09%), with widening gender disparities: male ASPR and ASDR rose (AAPC=0.77%, 0.31%), whereas female ASDR declined (AAPC=-0.27%). National trends were heterogeneous, with rising burden in Tokelau, Niue, and China, and declining burden in Estonia, Russia, and other Eastern European countries. ARIMA projections (2022–2027) show continued male burden increase and female decline. MNBAC burden in CAYA is rising globally with male predominance and cross-national variability, requiring targeted interventions for young males and tailored resource allocation.
Malignant neoplasms of bone and articular cartilage; Global burden of disease; Annual average percent change; Children, adolescents, and young adults
Xianfeng Kuang, Shaoquan Pu. Global, National, and Socioeconomic Disparities in Malignant Neoplasms of Bone and Articular Cartilage among Children, Adolescents, and Young Adults, 1990–2021: A Multilevel AAPC Analysis and Future Projection Based on the Global Burden of Disease Study 2021. Frontiers in Medical Science Research (2026), Vol. 8, Issue 3: 32-40. https://doi.org/10.25236/FMSR.2026.080305.
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