This article focuses on the potential value of fungal secondary metabolites in the health field, focusing on the impact of microecological regulation on their health value. In this study, the composition of fungal microecosystem and the characteristics of secondary metabolites were expounded, and the mechanism of microecological regulation affecting the synthesis of fungal secondary metabolites was deeply analyzed, including the regulation of environmental factors and the interaction between microorganisms. At the same time, the health regulation functions of fungal secondary metabolites on human immune system regulation, intestinal microecological balance maintenance, antioxidant and anti-inflammatory were studied. This article puts forward some strategies to improve its health value based on microecological regulation, such as optimizing culture conditions, using genetic engineering means and adopting microbial co-culture strategy. Microecological regulation is closely related to the synthesis and health function of fungal secondary metabolites. Rational use of relevant strategies can effectively enhance the health value of fungal secondary metabolites and provide theoretical basis and technical support for developing new health products.

Yao Song. Analysis of Health Value of Secondary Metabolites of Fungi Based on Microecological Regulation. Academic Journal of Medicine & Health Sciences (2026), Vol. 7, Issue 2: 78-82. https://doi.org/10.25236/AJMHS.2026.070211.

[1] Li S M, Zhou J C, He R, et al. Study on Secondary Metabolites of Marine Fungus Aspergillus terreus [J]. Natural Product Research and Development, 2023, 35(10): 1732-1738+1831. DOI:10.16333/j.1001-6880.2023.10.009.

[2] Singh V K, Kumar A. Secondary metabolites from endophytic fungi: Production, methods of analysis, and diverse pharmaceutical potential [J]. Symbiosis, 2023, 90(2): 111-125.

[3] Chen L, Wang M, Hu Y, et al. Analysis of Secondary Metabolite Differences in Medicinal and Edible Polygonatum sibiricum and Study on Active Components and Mechanism for Improving Insulin Resistance [J]. Natural Product Research and Development, 2022, 34(09): 1582-1596. DOI:10.16333/j.1001-6880.2022.9.016.

[4] Ran H M, Yin W B. Research Progress in Discovery of New Natural Products Based on Microbial Interactions [J]. Progress in Pharmaceutical Sciences, 2023, 47(04): 260-272. DOI:10.20053/j.issn1001-5094.2023.04.003.

[5] Shi Z T, Yang M L, Zhou Y R, et al. Research Progress on Ginseng Rhizosphere Microecology [J]. Chinese Journal of Microecology, 2024, 36(08): 974-979+984. DOI:10.13381/j.cnki.cjm.202408017.

[6] Liu Y T, Guo J, Zhang Z Y, et al. Research Progress on the Authenticity of Chinese Medicinal Materials from the Perspective of Rhizosphere Microecology [J]. Modern Chinese Medicine, 2025, 27(08): 1594-1602. DOI:10.13313/j.issn.1673-4890.20241213001.

[7] Xu X, Zuo J Y, Xiong R K. Mutagenic Breeding of Gibberellic Acid GA4+7 Producing Strain [J]. Chinese Journal of Antibiotics, 2024, 49(06): 662-666. DOI:10.13461/j.cnki.cja.007708.

[8] McCrory C, Lenardon M, Traven A. Bacteria-derived short-chain fatty acids as potential regulators of fungal commensalism and pathogenesis [J]. Trends in microbiology, 2024, 32(11): 1106-1118.

[9] Shankar A, Sharma K K. Fungal secondary metabolites in food and pharmaceuticals in the era of multi-omics [J]. Applied Microbiology and Biotechnology, 2022, 106(9): 3465-3488.

[10] Song G, Zhang Z, Niu X, et al. Secondary metabolites from fungi Microsphaeropsis spp.: chemistry and bioactivities [J]. Journal of Fungi, 2023, 9(11): 1093.