International Journal of Frontiers in Medicine, 2025, 7(3); doi: 10.25236/IJFM.2025.070313.
Shen Furong, Deng Wei
Department of Ophthalmology, Civil Aviation Flight University of China Hospital, Sichuan, Guanghan, 618307, China
This study focuses on the detection of corneal endothelial lesions among flight students at the Civil Aviation Flight Academy of China, aiming to delve into the principles of aviation medical identification for such lesions and assess whether flight students with these conditions pose safety risks in special aviation environments. Between March 2019 and March 2024, a cluster random sampling method was employed to select 24,810 flight trainees who underwent annual physical examinations at the Flight Personnel Physical Examination and Appraisal Center of the Civil Aviation Flight Academy Hospital of China. All the trainees received comprehensive ophthalmic examinations, encompassing assessments of naked - eye far vision, near vision, color vision, extraocular muscles, slit lamp microscopy, and direct ophthalmoscopy. The examination results were then subjected to statistical analysis. The findings revealed that a total of 55 flight trainees (80 eyes) were diagnosed with corneal endothelial lesions, yielding an overall detection rate of 0.22%. Specifically, 30 trainees (37 eyes) presented with corneal endothelial opacities accompanied by vesicular changes, with a detection rate of 0.12%, while 25 trainees (43 eyes) had simple corneal endothelial opacities, showing a detection rate of 0.10%. An analysis of corneal endothelial cell count in flight trainees with corneal endothelial lesions over the past three years indicated that as the years progressed, the corneal endothelial cell count gradually declined. However, this difference was not statistically significant (P < 0.05). In conclusion, the corneal endothelial lesions observed among the civil aviation flight students at our school are all in the early stages of the disease. These students exhibit good visual function status and meet the criteria for aviation medical identification. It is recommended to implement tracking and observation of these students, along with regular checks of their visual function and corneal physiological function indicators.
Flight Cadet; Corneal Endotheliopathy; Detection Rate
Shen Furong, Deng Wei. Detection Rate of Corneal Endothelial Lesions in Civil Aviation Flying Cadets. International Journal of Frontiers in Medicine (2025), Vol. 7, Issue 3: 94-99. https://doi.org/10.25236/IJFM.2025.070313.
[1] Geffen N, Topaz M, Kredy -Farhan L, et al. Phacoemulsification induced injury in corneal endothelial cells mediated by apoptosis: In vitro model. J Cataract Refract Surg 2008, 34 (12):2146-2152.
[2] Li Fengming, Xie Lixin. Chinese Ophthalmology [M] Beijing: People's Health Publishing House, 2014: 1996-1998
[3] Liskova P, Dudakova L, Evans CJ, et al. Ectopic GRH L 2 Expression due to non-coding mutations promotes cell state transition and causes posterior polymorphous corneal dystrophy 4. Am J Med Genet, 2018, 102(3): 447-459.
[4] Xie Cuijuan, Guo Yingjie, Hou Jie. Posterior polymorphic corneal dystrophy: 1 case each of vesicular, band, and diffuse types [J] Journal of Clinical Ophthalmology, 2024, 32(5): 457-459.
[5] Civil Aviation Administration of China, detailed rules for the implementation of medical standards for civil aviation physical examination and identification, 2024, 7(AC-67-FS-001R1)
[6] Shao Yi, Tan Gang, Chen Wei, et al. Standard operating guideline for non-contact imaging devices commonly used in ocular surface diseases(2023) [J]. Recent Advances in Ophthalmology, 2023, 43 (06): 421-428.
[7] Hong Jing, Yan Xiaoming, Sun Xuguang. Corneal endothelial disease [M] Beijing: People's Health Publishing House, 2019: 169-177
[8] Chaurasia S, Mittal R, Bichappa G, et al.Clinical characterization of posterior polymorphous corneal dystrophy in patients of Indian ethnicity[J] .Int Ophthalmol, 2017, 37(4): 945-952.
[9] Gu Shaofeng, Peng Rongmei, Xiao Gege, et al. Imaging features of posterior polymorphic corneal dystrophy under confocal microscopy [J] Chinese Journal of Ophthalmology, 2022, 58(2): 103-111.
[10] Pang Chenjiu, Jing Yang, Li Jin, et al. Clinical observation of posterior polymorphic corneal malnutrition [J] Chinese Journal of Ophthalmology, 2011, 47(1): 17-21.
[11] Weiss JS, Moller HU, Aldave AJ, et al.IC3D classification of corneal dystrophies--edition 2[J] . Cornea, 2015, 34(2): 117-159.
[12] Vaughan D, Asbury T, Riordan-Eva P. Genaral Ophthalmology [M] . New York: Mc Graw-Hill, 2001: 135.
[13] Del Turco C Pierro L, Querques G, et al.Posterior polymorphous corneal dystrophy concomitant to large colloid drusen[J] .Eur J Ophthalmol, 2015, 25(2): 177-179.
[14] Krachmer JH. Posterior polymorphous corneal dystrophy: a disease characterized by epithelial-like endothelial cells which influence management and prognosis [J] Trans Am Ophthalmol Soc, 1985, 83: 413-475.
[15] Sheng Xunlun, Zhu Dejun, Li Huiping, et al. Four cases of band shaped posterior polymorphic corneal endothelial malnutrition [J] Chinese Journal of Ophthalmology, 2014, 50(9): 699-701.
[16] Sekundo W, Lee WR, Kirkness CM, et al. An ultrastructural investigation of an early manifestation of the posterior polymorphous dystrophy of the cornea [J] Ophthalmology. 1994 Aug, 101(8): 1422.
[17] Katie E,Nicola P,Dimitrios V,et al. Utility of corneal confocal microscopy for assessing mild diabetic neuropathy: baseline findings of the LAND Mark study [J]. Clin Exp Optom, 2012, 95(3): 348-354.
[18] Lv Jian, Zeng Siming, Jiang Li, et al. Application and development of in vivo confocal microscopy in the diagnosis of microbial keratitis [J] International Eye Science, 2020, 20(12): 2070-2073.