As a cutting-edge discipline for solving tissue and organ damage repair and difficult disease treatment, the development of regenerative medicine highly relies on breakthroughs and transformations in stem cell technology. This article systematically reviews the research progress and clinical translation status of stem cell technology in the field of regenerative medicine, with a focus on analyzing the biological characteristics and application advantages of major cell types such as mesenchymal stem cells and induced pluripotent stem cells. It explores the innovative fusion achievements of key technologies such as directed differentiation, 3D bioprinting, and cell-free therapy. Research has shown that stem cell technology has made significant breakthroughs in the clinical translation of neurodegenerative diseases, metabolic diseases, cardiovascular diseases, and other fields. However, it still faces core challenges such as insufficient technical standardization, safety risk management, ethical regulatory adaptation, and broken industrial transformation chains. In the future, by promoting the precise and multidisciplinary integration of stem cell technology, improving the collaborative innovation system and standardized regulatory mechanism of "industry university research application", we can effectively break through the barriers to transformation. The research conclusion of this article provides theoretical reference for the high-quality development of stem cell technology in the field of regenerative medicine, helping it achieve a leap from laboratory research to large-scale clinical application, and providing revolutionary solutions for the treatment of difficult diseases.

Yuxin Li, Zhongqian Wu, Na Lu, Jie Xu. Research Progress and Clinical Translation Prospects of Stem Cell Technology in Regenerative Medicine. Academic Journal of Medicine & Health Sciences (2026), Vol. 7, Issue 1: 33-39. https://doi.org/10.25236/AJMHS.2026.070105.

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