Respiratory diseases are prevalent and frequently occur in various parts of the respiratory system. More and more studies have revealed the key role of traditional Chinese medicine (TCM) in treatment of respiratory diseases, but the active components of its function are still unclear and need to be further explored. In this study, the main components and potential targets of Shegan Qingwen Fuzheng Oral Liquid (SQFOL) were obtained through the TCMSP, HERB, and SwissTargetPrediction databases. The PPI network was constructed by combining STRING, and targets related to respiratory viral infections were screened using GeneCards, DisGeNET, and OMIM to establish a "component-target-disease" network. GO and KEGG enrichment analysis were then performed with the help of DAVID, and molecular docking was used to verify and visualize the core components and key proteins. PPI network analysis indicated that GAPDH, AKT1, TNF, IL6, and TP53 were potential hub proteins. The “drug–core target–disease” network identified quercetin, deacetylmatricarin, and linolenic acid as potential core active compounds. GO and KEGG analysis showed enrichment in the MAPK, PI3K–Akt, HIF-1, cancer, and human cytomegalovirus infection signaling pathways. Molecular docking confirmed that quercetin exhibited stable binding with hub proteins, particularly GAPDH. The therapeutic mechanism of SQFOL against respiratory viral infections may involve multi-component, multi-target, and multi-pathway regulation. These mechanisms are likely to contribute to the inhibition of viral replication, regulation of inflammatory responses, and maintenance of immune homeostasis.

Zhifei Hou, Qianhui Zhao, Limin Zhang, Xin Yang, Pei Liu, Haigang Lu, Xuening Zhang. Exploration of the Mechanism of Shegan Qingwen Fuzheng Oral Liquid in Treating Respiratory Infections Based on Network Pharmacology and Molecular Docking. Frontiers in Medical Science Research (2025), Vol. 7, Issue 6: 70-78. https://doi.org/10.25236/FMSR.2025.070608.

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