Aging is a natural phenomenon in the process of life, which is not only a research focus of modern medicine, but also a long-term topic of exploration in cell biology. Cell biology believes that aging is a process of cellular function degradation over time, which is influenced by multiple factors and mainly involves the following core mechanisms: cell apoptosis and failure, decreased mitochondrial function, shortened cell telomeres, and chronic low-grade inflammation. These mechanisms interweave with each other, gradually leading to "aging manifestations" such as skin laxity, cognitive decline, and metabolic decline.Golden Oyster Mushroom (Pleurotus citrinopileatus Sing.),  as a natural fungus with both medicinal and edible values, its active ingredient ergothioneine has been confirmed by modern research to have significant antioxidant, anti - glycation and skin aging - delaying effects. Based on the theory of "human aging originates from cell aging" in cell biology, combined with the 28 - day randomized double - blind clinical trial data of GOM - HCEr® ergothioneine from Golden  Oyster Mushroom, this study systematically explores its anti - aging effect. The test results show that continuous daily intake of 100mg GOM - HCEr®  can effectively improve the skin gloss (increased by 3.638%), elasticity (increased by 5.357%), water content (increased by 7.599%) and reduce the wrinkle area (decreased by 21.071%) of the subjects, and show significant advantages over the placebo group in anti - glycation reaction. Based on the theory of cell biology research, this experimental study believes that ergothioneine contained in GOM-HCEr® can delay skin aging through cell biological processes such as mitochondrial function protection, DNA repair, inflammatory aging regulation, and Sirtuin pathway activation.

Nurfarih Hanna, Mohd Zarif Fikri Bin Mohd, Muhammad Nabil Fikri Bin Mohd, Nurfarazuna Binti Mohd Fadrol. Mechanism and Clinical Study of Ergothioneine from Golden Oyster Mushroom on Anti - Aging Effects of Human Skin and Cells. Frontiers in Medical Science Research (2025), Vol. 7, Issue 4: 101-108. https://doi.org/10.25236/FMSR.2025.070413.

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