Frontiers in Medical Science Research, 2025, 7(4); doi: 10.25236/FMSR.2025.070411.
Hu Weixuan, Yan Jiali, Kou Lieling
Affiliated Ankang Hospital of Traditional Chinese Medicine, Shaanxi University of Chinese Medicine, Ankang, Shaanxi, 725000, China
Glaucoma is a chronic eye disease with a high global rate of blindness. Its damage to visual function is irreversible, mainly manifested as visual field defects and structural changes of the optic nerve. Although current Western medicine can effectively control intraocular pressure (IOP), it remains limited in slowing or halting the progressive loss of visual function. In recent years, Traditional Chinese Medicine (TCM) has shown unique advantages in the treatment of glaucoma, particularly in improving microcirculation, regulating neural function, and delaying disease progression. This paper systematically reviews the pathological mechanisms underlying visual function impairment in glaucoma and the traditional Chinese medical understanding of its pathogenesis. It focuses on recent advances in TCM interventions—including herbal compound prescriptions, single herbs and their extracts, acupuncture, and other methods—and discusses the current status and advantages of integrated TCM and Western medicine approaches. The paper also identifies current research limitations, such as the lack of high-quality evidence-based studies and standardized diagnostic classification, and proposes future directions involving deeper mechanistic exploration and more rigorous clinical protocols. This aims to provide new insights and theoretical support for the comprehensive prevention and treatment of glaucoma.
Glaucoma; Visual Function Impairment; Traditional Chinese Medicine; Herbal Compounds; Neuroprotection
Hu Weixuan, Yan Jiali, Kou Lieling. Progress in Traditional Chinese Medicine Treatment for Visual Function Impairment in Glaucoma. Frontiers in Medical Science Research (2025), Vol. 7, Issue 4: 84-90. https://doi.org/10.25236/FMSR.2025.070411.
[1] Sim, Ru Hui, et al. "Treatment of glaucoma with natural products and their mechanism of action: An update." Nutrients 14.3 (2022): 534.
[2] Li, Wencan, et al. "Progress in traditional Chinese medicine on treatment of diabetic retinopathy." Natural Product Communications 17.8 (2022): 1934578X221118547.
[3] Li, Yuli, et al. "Non-neglectable therapeutic options for age-related macular degeneration: A promising perspective from traditional Chinese medicine." Journal of Ethnopharmacology 282 (2022): 114531.
[4] Liu, Hongji, et al. "Efficacy and safety of Bujing Yishi tablet for glaucoma with controlled IOP: study protocol for a multi-centre randomized controlled trial." Trials 21 (2020): 1-11.
[5] Ling, Jiawei, et al. "Current advances in mechanisms and treatment of dry eye disease: toward anti-inflammatory and immunomodulatory therapy and traditional Chinese medicine." Frontiers in Medicine 8 (2022): 815075.
[6] Li, Min, et al. "Autophagy in glaucoma pathogenesis: Therapeutic potential and future perspectives." Frontiers in Cell and Developmental Biology 10 (2022): 1068213.
[7] Zhu, Jingyuan, et al. "Oral scutellarin treatment ameliorates retinal thinning and visual deficits in experimental glaucoma." Frontiers in medicine 8 (2021): 681169.
[8] Lakshmanan, Yamunadevi, et al. "Potential role of Lycium barbarum polysaccharides in glaucoma management: evidence from preclinical in vivo studies." Neural regeneration research 18.12 (2023): 2623-2632.
[9] Liang, X. B., J. J. Wang, and Keshav Narain. "The use of acupuncture in eye diseases: An overview." Open Access J Complement Altern Med 2 (2020): 237-242.
[10] Liu, Peiyu, et al. "Current situation and progress of drugs for reducing intraocular pressure." Therapeutic advances in chronic disease 13 (2022): 20406223221140392.