This study reports a rare case of diffuse large B-cell lymphoma (DLBCL) complicated with active pulmonary tuberculosis. The patient, after undergoing R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone) chemotherapy, developed respiratory distress and cough, eventually diagnosed as pulmonary tuberculosis. Clinical analysis reveals that lymphoma patients are at increased risk of reactivating latent tuberculosis infection (LTBI) due to immunosuppression caused by the disease itself and immunosuppressive treatments. This case underscores the importance of latent TB screening in lymphoma patients during treatment to prevent opportunistic infections. Moreover, the study discusses the challenges of implementing simultaneous anti-tuberculosis and anti-tumor therapies, providing valuable insights for clinicians to optimize diagnosis and treatment strategies.

Qi Zhou, Mingyi Li, Jinxiu Wang, Hongyan Zhang, Xuejuan Yang,  Lin Mao. One case of intervariable diffuse large B cell lymphoma mixed with pulmonary tuberculosis. Frontiers in Medical Science Research (2025), Vol. 7, Issue 1: 34-39. https://doi.org/10.25236/FMSR.2025.070105.

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